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#622Genesis"In the beginning"Active item (one time use)
Resets all of Isaac's stats and transformations, removes the floor's curses, and removes all of Isaac's items, except his starting ones and those with the quest tag, and teleports him to a special Bedroom.

The Bedroom contains a Bed, 2 random Chests, 2 Grab Bags, a random trinket, and a beam of light that can be used to exit the room and go down to the next floor.

For every item removed by Genesis, a set of 3 choice-pedestals will spawn in the room containing items from the same item pool as the removed item. Only one of these items can be taken. Each set appears one after the other.

If used on a final floor of the game, the beam of light will be replaced with a Crawl Space that leads back to the starting room of the floor.

Trinkets that were absorbed will simply be removed from Isaac's inventory with no extra item pedestals granted for them.

Picking up an active item from the choice of items will not drop it on the ground, but instead replace it with the new item.

Genesis affects all players in the run.

Unlock: Defeat Ultra Greedier as Jacob and Esau.

- Tags -- Synergies -- Links -

▾ITEMS ()▾

D infinityDogmaJar of WispsFlipEverything JarFiddle CubeDogboardGhastly Flame

▾TRINKETS ()▾

Extra VesselVessel RockDogrock RockSand CastleFractal Geode

▾PICKUPS ()▾

HeartHeart (half)Heart (soul)Heart (eternal)Heart (double)Black HeartGold HeartHeart (half soul)Scared HeartBlended HeartBone HeartRotten HeartPennyNickelDimeDouble PennyLucky PennySticky NickelGolden PennyKeyGolden KeyKey RingCharged KeyGolden BombGolden Troll BombGiga BombMega ChestMom's ChestMega BatteryGolden BatteryHalf Black HeartBlended Black HeartHalf Immoral HeartImmoral HeartBlended Immoral HeartMorbid HeartTwo-Thirds Morbid HeartThird Morbid HeartFull Eternal HeartDouble Full Eternal HeartCursed PennyGolden Cursed PennyHaunted PennyHoney PennyLego StudTokenCharged Spicy KeySuper Charged Spicy KeyFirework BatteryVirtuous BatteryBlood SackDire Chest

▾CONSUMABLES ()▾

HagalazJeraEhwazDagazAnsuzPerthroBerkanoAlgizGolden PillGolden Horse PillStorage BatteryCorroded Battery

▾MACHINES/BEGGARS ()▾

Slot MachineBlood Donation MachineFortune Telling MachineBeggarDevil BeggarShell GameKey MasterDonation MachineBomb BumShop Restock MachineGreed Donation MachineMom's Dressing TableBattery BumHell GameCrane GameConfessionalRotten BeggarMining MachineBismuth BeggarSourpussUnfinished GolemGeode GolemBabiMidarizerSweetpussBlacksmithZodiac BeggarRobot TellerEvil BeggarFake BeggarDealerCell GameHug BeggarCosplay BeggarPhone BoothGolden Slot MachineJukeboxVending MachinePoker TableGrid Restock MachineRevending MachineVanity StatwheelSewing Machine

▾CHARACTERS ()▾

MagdaleneSamsonAzazelLilithBethanyTainted MagdaleneTainted EveTainted LilithTainted Bethany

▾CURSES ()▾

▾OTHER ()▾

Pact of ChampionsPact of FragilityPact of FrostPact of GroundingPact of HemorrhagePact of Ice WraithPact of MasochismPact of MischiefPact of MitosisPact of ParanoiaPact of PerilPact of PunishmentPact of PurgatoryPact of RevivalPact of Scarcity